It has been confirmed that Prison Break will return for a short series next year.
The show will be back for a 10 episode sequel that brings back both Wentworth Miller and Dominic Purcell to the series.
I would describe it as a bit of a sequel. It picks up the characters several years after we left them in the last season of the show. The brothers will be back. Some of the iconic characters from that show will be back. I don’t think [exec producer] Paul [Scheuring] knows exactly where he’s going over the 10-episode arc, but it definitely will address some questions that were set up at the end of the series for a new audience. FOX CEO Dana Walden said
“This is the pure vision of the creator of the show,” continued. “It’s going to take a little bit of a detour from where we left off [with the straight-to-DVD coda], but it should feel very satisfying and event-sized. Fans will be excited about seeing these characters back together again.”
As for how Miller’s character Michael returns given he died in the final episode time will tell.
Source TV Line